I’m sorry, but I believe you are still trying to install directly from the .zip folder.
I found a spare machine running Windows 10 and saved a copy of the downloaded DVD_Version_N1_126.96.36.199.242_CE.zip file to the desktop. When I right clicked on it and selected Open (with Explorer), moved down to the next lower directory and executed the Setup.exe file there, I eventually got the same error message you did.
However, when I right clicked on the downloaded file and selected Extract, and then created a new permanent directory where the extracted files were created, I was able to successfully run the Setup.exe in that directory which successfully completed the installation.
Note when you run the Extract, you can change the name of the top directory you are creating so you can tell them apart, or put the extracted files in a completely different directory, like under Documents, or I like to use the Downloads directory under Documents. Also to check if you are using the .zip file or not, you can right click on it and select Properties. For the .zip file the 2nd line of the Properties display shows “Type of file: Compressed (zipped) folder (.zip)” The Properties for the new extracted directory will show “Type: File folder (.242_CE)”
Another tip, once you have created the extracted directory, and before running the Setup, click on the ReadmeFirst file, read or print it out, and keep following the links to Getting Started, Next “Installation”, Next “Starting NaturalONE for the First Time”.
Hope that helps. Good luck.