MQ adapters v6.0.1

Hello! I am doing an initial install of WebMethods v6.0.1 and we want to use the MQ adapter to talk to MQ which is residing on the same box. My questions are …
1- since the two s/w are on the same box do I need to define anything special on MQ

2- I have 75 inbound queues and 50 outbound queues which will be using a transactional type on connection . do I need to define multiple connection or can I just define one for transactional type of processing and add all the queues to that one ?
tkank you.
Eddy Girard