HTTP/1.1 401 [ISS.0084.9001] Invalid credentials

I am getting this error with a couple of the integrations (AS2) that I am testing with.
Any ideas?
[SIZE=4][COLOR=#000080][SIZE=4][COLOR=#000080]HTTP/1.1 401 [ISS.0084.9001] Invalid credentials

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So not just wrong username/password (or failed to set user/pass on the request?)