Error when executing asynchronous RFC via RFC destination xx

Hi,

I created a RFC function in SAP ECC 6.0. I could send data to B2B Developer 46 successfully. I then modified the program to invoke the RFC function as asynchronous RFC to wait for data return from B2B. However, I’m getting error message “Error when executing asynchronous RFC via RFC destination xxx”.

Do I need to set up the RFC destination differently for ARFC?

Any info is appreciated.