Perhaps your partner has a firewall in place somewhere on their side that is closing the connection. Your network team may need to perform some traces, etc. to determine the precise cause.
How are you authenticating with this client system?
If using cert, the client system may not trusting your cert.
If username/password, check if the password is correct.
Hi Nikhil,
You may be able to narrow down the issue to a specific cert problem by changing the delivery to plain (unencrypted/unsigned) to see if that works. In TN this is the SMIME value in the partner profile EDIINT extended settings. Your partner will need to make compatible changes on their side. If the delivery works, you can adjust the settings again (signed, but not encrypted, etc.). Also, is this HTTP or HTTPS?
-Mary