TN hangs in 4.6

We are using IS 4.6, TN. we are not using JDBC Adapter. Alternate day TN is getting hanged. Number of Connection to Datebase are well with in the limit. TN connects to database using Sequel link. To resolve the issue temporarly we are restarting the Sequel link. After restart of sequel link TN works fine for some time but again gets hanged after 36-48 hrs(approx).
Any inputs will be highly appriciated.
Thanks in Advance,