Self Signed Certificate client to WM7.1

We have several partners connecting to Webmethods 7.1 through
Https using certificates using certificates.But few partners are facing issues while connecting to WM7.1.Those partners are using self signed certificates.We came to conclusion that the issue is because of self signed certificates.

Is there any possibility that the clients can use self signed certificates to connect to webmethods server?.To make it work for self signed certificates what are all the settings need to be done in Webmethods 7.1 side(both on RG and internal).
Please help me in this regard

Thanks in Advance

try placing the self signed certificate in the CA certificate directory and refresh the CA cache