SAP RFC not work well in IS server

In our IS 6.1 server,connect to SAP via SAP Adapter4.6,and the version of SAP is 4.7,
the RFC invoke coundn’t work well,if the version of SAP is 4.6,the RFC worked well,how to solve this problem ?

You’re going to have to be a lot more specific about what not working well means.

Are there any problems with the Adapter connecting to SAP to generating services?
Are the services created correctly? Look at the inputs and outputs of the services in Developer.
Are you using other types of SAP services (non-RFC)? If so, do of them work?
Is there an exception?
Is there any information in the Integration Server log?
Has any RFC call ever worked in your environment for any other Integration Server?