Any IS version dependency
As long as running on IS server currently in support and also certified to run with SAP Adapter 7.1 or SAP Adapter 10.1
Any special connectivity consideration on on-premise S/4 HANA, any tunneling required if S/4 HANA hosted on AWS.
This should be best checked with SAP AG support, by asking them whether third party software connecting to SAP S/4 HANA hosted on AWS/Azure requires any additional step.