Error in creation of Broker Alias in Integration Server

I have installed

  1. Integration server 4.6 , running in localhost:5555

2.Enterprise Server 4.1.1 Running in Local Host:6849

  1. I Installed Broker package 4.6

When I try to create a broker alias from IS Admin

I filled input like

Alias Name : alias1
Min Clients : 3
max Clients : 9
Broker Name : br1 ( I created in Enterprise Server)
Broker Host : localhost
port : 6849 (default)

pressed Save

it is talking a lot of time and exiting with message like " Error in creating Clients
cannot create webmethodsb2bClients Client group
Initialising localhost:6849 timeout

please give me your Idea