JDBC Adapter problem

Hi Everybody,
can any one help me in this issue:
when I am trying to enable the JDBC Adapter conn it is showing this error:

[ART.118.5042] Adapter Runtime (Connection): Unable to enable connection resource Sesha:JDBCAdapter_sesha.
[ART.118.5063] Adapter Runtime (Connection): Unable to start connection Sesha:JDBCAdapter_sesha: after 1 attempt(s).
[ART.118.5036] Adapter Runtime (Connection): Unable to configure connection manager.
[ADA.1.204] Cannot connect to the database with DataSource class “oracle.jdbc.pool.OracleDataSource”.

Io exception: Connection refused(DESCRIPTION=(TMP=)
(VSNNUM=153092352)(ERR=12505)(ERROR_STACK=(ERROR=(CODE=12505)(EMFI=4))))

Verify your JDBC DB connection settings to ensure they are correct. You may have some wrong info there. Also, try to connect using other client software (ie. Toad, sqlplus, etc.).

Connection refused is usually an indication of an incorrect port. Or an incorrect hostname/IP–right port, wrong machine.

Consult DBA for getting correct TNS settings as there may be possible change of port for security reasons(firewall or Proxy Settings).