java.lang.reflect.InvocationTargetException

java.lang.reflect.InvocationTargetException : com/wm/app/tn/tspace/ReservationAgent

When I attemp to send a large document with wm.ip.ebxml.MSH:sendUsingTPA or wm.ip.ebxml.MSH:send,I get the error.
But I send the large document with wm.EDIINT:send,it work successed. Can somebody help me?
thanks a lot!

configure:
http://127.0.0.1:5555/WmTNWeb/ ----> TN Properties
tn.archive.archiveAfterDays = 0
tn.archive.deleteAfterDays = 2
tn.BigDocThreshold = 500000
tn.certDir = cert
tn.cluster.notifyCacheChange = true
tn.cluster.notifyProfileAddUser = true
tn.cluster.notifyPropertyChange = true
tn.ff.contenttypes = text/plain
tn.mail.from = tn@webmethods.com
tn.query.threshold = 50
tn.receive.clearKeys = node,bizdoc,sender,receiver,flags,ffdata,TN_Parms
tn.receive.clearTNObjects = true
tn.required.idType = DUNS
tn.task.maxRetries = 5
tn.task.notifyFailure = false
tn.task.retryFactor = 1
tn.task.sweepTime = 300
tn.task.ttw = 300
tn.webmgr.60config = true
tn.xml.xqlThreshold = 50000