Shawn,
There are several ways of accessing/integrating with the AS/400:
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WmJDBCAdapter - as long as the IBM Java Tool kit is install on your AS/400, then you can configure the connector like any other database connection and create integrations using the template operations that are available to SQL
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AS/400 Adapter 6.0.1
The webMethods AS/400 Adapter is an add-on to the webMethods Integration Server that enables you to exchange data with IBM AS/400 servers through the use of the IBM ToolBox for Java or JTOpen. The adapter provides seamless and real-time communication with the AS/400 server. Using the AS/400 Adapter, webMethods clients can create and run services that execute commands and programs, and read and write data from data queues on an AS/400 server. -
WmDB
Using the ODBC driver provided by IBM, you can also connect to the AS/400 without the need of IBM ToolBox for Java.