Upload a base64-Picture-String via event message (thinedge) to Cumulocity

Could you please tell us a bit about the use case.

Images can not be uploaded via mqtt directly but via Rest. There is currently an feature request open for that:

https://github.com/thin-edge/thin-edge.io/issues/1315

However you could handle the RestCall in your own plugin and attach it to an event. @Harald_Meyer referenced the API call already for that.